Pritzker Neuropsychiatric Disorders Research Consortium
The Pritzker Neuropsychiatric Disorders Research Consortium seeks to discover the neurobiological and genetic causes of three major psychiatric disorders, Major Depressive Disorder, Bipolar Disorder and Schizophrenia. The Pritzker Consortium also seeks to identify biomarkers and novel targets for drug development. The Consortium conducts studies to identify genetic alterations in brain circuits associated with mood disorders and consists of investigators involved in all aspects of the scientific process from basic to clinical research, from genetics to neuroscience. The multi-dimensional approach is also bi-directional, in that the research process starts with human postmortem brain tissue proceeds to animal models and circles back to individuals with psychiatric disorders to translate our knowledge into benefits for patients.
Hope for Depression Research Foundation – Depression Task Force
HDRF is supporting research specifically aimed at understanding the causes of treatment resistance and identifying new approaches to reverse it. The Foundation’s starting place is to address the questions: Why are some depressed people resistant to treatment? How does resistance develop and why does the course of the illness deteriorate?
To tackle this challenge, HDRF has assembled a premier group of neuroscientists and physicians who focus on the brain biology of emotions, mood and depression. They also are pioneers in the area of “neuroplasticity” — the ability of the brain to remodel itself based on experience. Some of this brain remodeling can be beneficial, for example in learning new information. But some remodeling can be damaging as the brain becomes “stuck” in negative emotions even in the absence of external triggers — as is the case with severe, recurring, treatment resistant depression. The goal of the HDRF scientists is to discover the brain changes that lead to this state of being “stuck” and target them for reversal. This includes identifying factors that make certain individuals particularly resistant to stressful life events, and boosting such natural resilience mechanisms in depressed patients.
UMHS-PUHSC Joint Institute for Translational and Clinical Research
The Joint Institute for Translational and Clinical Research is a unique partnership between the University of Michigan Health System and Peking University Health Sciences Center. Officially launched in October 2010 with a combined commitment of $14-million, the Joint Institute sponsors high-impact collaborative research that leverages the unique strengths of each university to advance global health.